News

Say goodbye to jet lag

Say goodbye to jet lag

Photo: clipart.com

LONDON (Reuters) – Scientists have found a genetic mechanism in mice that hampers their body clock’s ability to adjust to changes in patterns of light and dark, and say their results could someday lead to the development of drugs to combat jet lag.

Researchers from Britain’s Oxford University and from the Swiss drug firm Roche used mice to analyze patterns of genes in an area of the brain called the suprachiasmatic nuclei (SCN) – which in mammals pulls every cell in the body into the same biological rhythm.

They found that one molecule, called SIK1, is key to how the mice responded to changes in light cycles.

When the scientists blocked the activity of SIK1, the mice recovered faster from disturbances in their daily light and dark cycle that had been designed to induce a form of mouse jet lag.

If the corresponding mechanism can be found and similarly blocked in humans, jet lag may become a thing of the past, the researchers said in their study, published online in the journal Cell on Thursday.

“We’re still several years away from a cure for jet lag, but understanding the mechanisms that generate and regulate our circadian clock gives us targets to develop drugs to help bring our bodies in tune with the solar cycle,” said Russell Foster, director of Oxford’s sleep and circadian neuroscience institute.

He said such drugs could also have broader potential value, including for people with mental illnesses where sleep disturbances are common.

Recent Headlines

in Entertainment

Stay Puft Marshmallow Man ruins your favorite movie

stay-puft

Again, the internet proved it's awesomeness with #AddAPuftRuinAMovie. These are some of our favorites!

in Entertainment

Countdown: Supporting characters that need their own movie

From left: Jon Gries (Uncle Rico), Jon Heder (Napoleon Dynamite) and Aaron Ruell (Kip) in "Napoleon Dynamite," a comedy about a quirky teenager growing up in the remotes of Idaho, trying to understand his life.

Which of these supporting characters should have their own movies?

in Music

Shania Twain will end her Vegas run in December

shania

The country star will end a two-year Vegas residency later this year.

in Entertainment

Zach Braff: Not dating Taylor Swift

zachbraff

The "Scrubs" star says he isn't dating the "Love Story" hitmaker.

in Entertainment

You can watch every episode of ‘The Simpsons’ in epic marathon

simpsons

A Web site and app features on-demand access to all 500 episodes and let users search through the life stories of the characters.